点击图片查看原图
菌株均为非甲醇型的毕赤酵母，采用流加甘油指数补料，产物外泌表达，发酵周期预计约90小时。
饲料级产品发酵结束后，碟片式离心分离，陶瓷膜微滤，超滤(3 kDa)，最后加载体喷雾干燥，获得粉末产物
食品级产品发酵结束后，经碟片式离心分离（或板框压滤），超滤，离子交换，除内毒素，除菌，喷雾干燥等步骤，获得粉末产物
Peptobiotics is currently looking for contract manufacturers for several of our products, including both feed-grade and food-grade products.
The feed-grade product has already undergone pilot-scale testing, and we are now looking to scale up to a production capacity of 30 to 100 tons. For the food-grade product, we are currently seeking partners for pilot-scale trials and long-term production cooperation.
We would like to learn more about your equipment and capabilities to see if there’s an opportunity for further collaboration.
All strains used are non-methanol-utilizing Pichia pastoris, with fed-batch glycerol feeding strategies. The product is secreted extracellularly, and the fermentation cycle is expected to last around 90 hours.
For the feed-grade product, after fermentation, the process includes:
• Disc-stack centrifugation
• Ceramic membrane microfiltration
• Ultrafiltration (3 kDa)
• Final spray drying with carrier to obtain the powdered product
For the food-grade product, after fermentation, the process includes:
• Disc-stack centrifugation (or plate-frame filtration)
• Ultrafiltration
• Ion exchange
• Endotoxin removal
• Sterile filtration
• Spray drying to obtain the powdered product
